A look into Anaphylaxis

Versions

PDF (Español (España))
Texto (Español (España))

Keywords

Anafilaxia
Hipersensibilidad
Hipersensibilidad a los Alimentos
Hipersensibilidad a las Drogas
Venenos de Artrópodos
Adrenalina Anaphylaxis
Hypersensitivity
Food Hypersensitivity
Drug Hypersensitivity
Arthropod Venoms
Epinephrine

How to Cite

Tello-Cajiao, M. E., & Vásquez, L. del M. (2023). A look into Anaphylaxis. Interdisciplinary Journal of Epidemiology and Public Health, 5(2), e–9888. https://doi.org/10.18041/2665-427X/ijeph.2.9888 (Original work published December 30, 2022)

Abstract

Introduction: Anaphylaxis is the most severe and potentially lethal presentation of acute systemic allergic reactions. Understanding its mechanisms provides a better diagnostic and therapeutic approach.

Objective: to present the key concepts of the mechanisms of anaphylaxis, its diagnosis, and its management in clinical practice.

Methods: a summary of the main concepts on the mechanisms, diagnosis, and management of anaphylaxis in clinical practice was made according to the review presented at the congress of the Asociación Colombiana de Medicina Interna (ACMI) Capítulo Valle, Universidad Libre: "A multidisciplinary approach with a Latin American vision" on May 13th and 14th, 2022.

Results: Anaphylaxis may affect 5% of people at some time in their lives. The main allergens are drugs, food, and Hymenoptera venom, but the cause may vary throughout the life cycle. The diagnosis is made according to the criteria of the World Allergy Organization and is confirmed by the determination of serum tryptase in case of doubt. Adrenaline intramuscular is the first line of treatment. Once the episode is over, evaluation by an allergy expert is always necessary.

Conclusion: identification and adequate treatment of anaphylaxis save lives. In the approach to the patient with anaphylaxis, it is important to identify the allergen and the factors associated with the episode to prevent a new one.

https://doi.org/10.18041/2665-427X/ijeph.2.9888
PDF (Español (España))
Texto (Español (España))

References

Cardona V, Ansotegui IJ, Ebisawa M, El-Gamal Y, Fernandez Rivas M, Fineman S, et al. World allergy organization anaphylaxis guidance 2020. World Allergy Organization J. 2020; 13(10): 100472. DOI: 10.1016/j.waojou.2020.100472

Cardona V, Álvarez-Perea A, Ansotegui-Zubeldia IJ, Arias-Cruz A, Ivancevich JC, González-Díaz SN, et al. Clinical practice guide for anaphylaxis in Latin America (Galaxia-Latam). Rev Alerg Mex. 2019; 66: 1 39. DOI: 10.29262/ram.v66i6.588

Umasunthar T, Leonardi-Bee J, Turner PJ, Hodes M, Gore C, Warner JO, et al. Incidence of food anaphylaxis in people with food allergy: A systematic review and meta-analysis. Clin Experim Allergy. 2015; 45(11): 1621 36. DOI: 10.1111/CEA.12477

Turner PJ, Campbell DE, Motosue MS, Campbell RL. Global trends in anaphylaxis epidemiology and clinical implications. J Allergy Clin Immunol Pract. 2020; 8(4): 1169. DOI: 10.1016/J.JAIP.2019.11.027

Yu JE, Lin RY. The Epidemiology of anaphylaxis. Clin Rev Allergy Immunol. 2018; 54(3): 366 74. DOI: 10.1007/s12016-015-8503-x

Solé D, Ivancevich JC, Borges MS, Coelho MA, Rosário NA, Ardusso LRF, et al. Anaphylaxis in Latin America: a report of the online Latin American survey on anaphylaxis (OLASA). Clinics (Sao Paulo). 2011; 66(6): 943 7. DOI: 10.1590/S1807-59322011000600004

Caraballo L, Zakzuk J, Lee BW, Acevedo N, Soh JY, Sánchez-Borges M, et al. Particularities of allergy in the Tropics. World Allergy Organization J. 2016; 9(1): 1 44. DOI: 10.1186/S40413-016-0110-7

Sánchez J, Sánchez A. Epidemiology of food allergy in Latin America. Allergol Immunopathol (Madr). 2015; 43(2): 185 95. DOI: 10.1016/J.ALLER.2013.07.001

Beltrán-Cárdenas CE, Granda-Restrepo DM, Franco-Aguilar A, Lopez-Teros V, Arvizu-Flores AA, Cárdenas-Torres FI, et al. Prevalence of food-hypersensitivity and food-dependent anaphylaxis in colombian schoolchildren by parent-report. Medicina (B Aires). 2021; 57(2): 146. DOI: 10.3390/MEDICINA57020146

Krystel-Whittemore M, Dileepan KN, Wood JG. Mast cell: A multi-functional master cell. Front Immunol. 2016; 6: 620. Doi: 10.3389/FIMMU.2015.00620/BIBTEX

Thangam EB, Jemima EA, Singh H, Baig MS, Khan M, Mathias CB, et al. The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: The hunt for new therapeutic targets. Front Immunol. 2018; 9: 1873. DOI: 10.3389/fimmu.2018.01873

da Silva EZM, Jamur MC, Oliver C. Mast Cell Function: A new vision of an old cell. J Histochem Cytochem. 2014; 62(10): 698 738. DOI: 10.1369/0022155414545334

Reber LL, Hernandez JD, Galli SJ. The pathophysiology of anaphylaxis. Journal of Allergy and Clinical Immunology. 2017; 140(2): 335 48. DOI: 10.1016/j.jaci.2017.06.003

Spoerl D, Nigolian H, Czarnetzki C, Harr T. Reclassifying anaphylaxis to neuromuscular blocking agents based on the presumed patho-mechanism: IgE-mediated, pharmacological adverse reaction or « innate hypersensitivity »? Int J Mol Sci. 2017; 18(6):1223. Doi: 10.3390/IJMS18061223

Cardona V, Álvarez-Perea A, Ansotegui IJ, Arias-Cruz A, González-Díaz SN, Latour-Staffeld P, et al. Manejo de la anafilaxia en América Latina: situación actual. Rev Alerg Mex. 2017; 64(2): 171 7. Doi: 10.29262/RAM.V64I2.250

Ribeiro MLKK, Chong Neto HJ, Rosario Filho NA. Diagnosis and treatment of anaphylaxis: there is an urgent need to implement the use of guidelines. Einstein (Sao Paulo). 2017; 15(4): 500 6. Doi: 10.1590/S1679-45082017RW4089

Ring J, Klimek L, Worm M. Adrenaline in the acute treatment of anaphylaxis. Dtsch Arztebl Int. 2018; 115(31 32): 528. Doi: 10.3238/arztebl.2018.0528

Simons FER, Gu X, Simons KJ. Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol. 2001; 108(5):871 3. Doi: 10.1067/MAI.2001.119409.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2022 Interdisciplinary Journal of Epidemiology and Public Health

Downloads

Download data is not yet available.