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Tetrandrine: as an emerging treatment for silicosis

Authors

DOI:

https://doi.org/10.18041/2322-634X/rcso.2.2021.7901

Keywords:

Silicosis, tetrandrine, work medicine, occupational diseases

Abstract

Silicosis is a lung disease caused by the inhalation of silica particles, characterized by acute inflammation in some cases and chronic inflammation in other cases. It can be associated with posterior diffuse fibrosis, leading to progressive respiratory failure.1 It is one of the most dangerous occupational diseases and is responsible for some 10,000 or more new deaths each year

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Author Biography

  • Diemen Delgado García, Universidad de Texas-Valle del Río Grande. Texas, USA

    Surgeon. Doctorate in Occupational Health Sciences. Research Line in Occupational Respiratory Diseases, University of Guadalajara. Specialist in Public Health with a Mention in Occupational Health, University of Chile. Director of Air Pneumo Chile - Latin America. Professor of Occupational Health at prestigious universities in Latin America. Author of articles and books related to Occupational Health.

References

Delgado GD, Rivera LP, Mahmood SN, Ramirez YO, Agila PE, Delgado CA. Silicosis: Origins and Consequences. Am J Medical Sci Med. 2019; 7(3): 60-63. doi: 10.12691/ajmsm-7-3-2.

Barnes H, Goh NSL, Leong TL, Hoy R. Silica-associated lung disease: an old-world exposure in modern industries. Respirology. 2019; 24:1165-75.

Menéndez-Navarro A, Cavalin C, García GM, Gherasim A. La remergencia de la silicosis como enfermedad profesional en España, 1990-2019. Rev Esp Salud Pública. 2021; 95: e202108106.

Salahuddin M, Cawasj Z, Kaur S. Estrada-Y-Martin RM, Cherian SV. Current concepts in pathogenesis, diagnosis, and management of silicosis and its subtypes. Curr Pulmonol Rep. 2021; 10, 135–142

Wu Q, Gui W, Jiao B, Han L, Wang F. MiR-138 inhibits epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by regulating ZEB2. Toxicology. 2021; 461: 15292

Garcia D, Sultan NM, Yerba OR, Castro SJ, Palacios EA, Cano AD. Silicosis and smoking: intrinsic phenomenon in the respiratory system. Adv Appl Sociol. 2018; 8: 659-667. Doi: 10.4236/aasoci.2018.810039

Song M-Y, Wang J-x, Sun, Y-l, Han Z-f, Zhou Y-t, Liu Y, et al. Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages. Acta Pharmacol Sin. 2021; Doi: 10.1038/s41401-021-00693-6

- Sun J, Song P, Wang Y, Chen Y. Clinical efficacy of acetylcysteine combined with tetrandrine tablets in the treatment of silicosis and the effect on serum IL-6 and TNF-α. Exp Ther Med. 2019; 18:3383–8.

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Published

2021-11-12 — Updated on 2021-11-19

Versions

Issue

Vol. 11 No. 2 (2021): Revista Colombiana de Salud Ocupacional

Section

Editorial

License

Copyright (c) 2021 Revista Colombiana de Salud Ocupacional

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite

Tetrandrine: as an emerging treatment for silicosis. (2021). Revista Colombiana De Salud Ocupacional, 11(2), e-7901. https://doi.org/10.18041/2322-634X/rcso.2.2021.7901 (Original work published 2021)

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