Niveles de fenol y presencia de micronúcleos en trabajadores de estaciones servicio
Phenol levels and presence of micronuclei in service station workers
DOI:
https://doi.org/10.18041/2322-634X/rcso.2.2018.5694Keywords:
benzene, phenol, micronuclei, gasoline, exposureAbstract
Introduction: The service station workers are daily exposed to benzene, causing various neurological, mutagenic and hematological alterations in them. Objective: The study aimed to determine the concentration of phenol and to show the presence of micronuclei in lymphocytes in service station workers. Methods: A descriptive, cross-sectional field study was carried out in which 35 workers from 4 service stations in a municipality in the state of Aragua, Venezuela and 35 workers without occupational exposure participated. Urinary phenol levels and the presence of micronuclei in lymphocytes were determined. Results: There was a significant difference in the concentration of urinary phenol between the exposed and the unexposed group, with association or relationship with seniority. 74.2% of the exposed group presented micronuclei. Conclusions: The findings of this study show a high interaction of benzene with the personnel in charge of dispensing gasoline at the stations, which indicates that measures must be taken to avoid pathologies associated with this exposure.
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References
2. Brizuela J, Jiménez Y. Niveles urinarios de fenol y ácido hipúrico en trabajadores de una empresa de pintura automotriz. Salud Trab. 2010; 18:107-15.
3. Córdoba D, Cuestas F. Tóxicos hematológicos.Toxicología.5ª ed .Editorial Manual Moderno, Bogotá, Colombia, 2006. pp. 361.
4. Snyder R, Hedli C. An overview of benzene metabolism. Environ Health Perspect. 1996; 104(6):1165-71.
5. Falzone L, Marconi A, Loreto C, Franco S. Spandidos D. Occupational exposure to carcinogens: Benzene, pesticides and fibers. Mol Med Reports.2016; 14(1):4467-74.
6. Haro J, Vélez N, Aguilar G, Guerrero S, Sánchez V, Muñoz S, et al. Alteraciones hematológicas en trabajadores expuestos ocupacionalmente a mezcla de benceno- tolueno-xileno (btx) en una fábrica de pinturas. Rev Peru Med Exp Salud Pública. 2012; 9(2): 81-87.
7. Barreto G, Madureira D, Capani F, Aon-Bertolino L, Saraceno E, Alvarez-Giraldez LD. The role of catechols and free radicals in benzene toxicity: An oxidative DNA damage pathway. Environ Mol Mutagen. 2009; 50:771-80.
8. Heuser VD, de Andrade VM, da Silva J, Erdtmann B. Comparison of genetic damage in Brazilian footwear-workers exposed to solvent-based or water-based adhesive. Mutat Res. 2005; 58(3):85-94.
9. Khalade A, Jaakkola M, Pukkala E, Jakola JK. Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis. Environ Health. 2010; 9(31):32-45.
10. Godinez N, Hidalgo S, Medina L. Estudio exploratorio sobre exposición inhalatoria a benceno en catorce estaciones de servicio dentro de las provincias del valle central de Costa Rica.(Trabajo de especialización) Instituto Tecnológico de Costa Rica: Costa Rica;2017
11. McHale CM, Zhang L, Smith MT.Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis. 2012; 33(2):240-52.
12. Romero B, Palencia A, Marrero S, Moran A. Evaluación de la exposición a benceno en trabajadores de diferentes áreas laborales. Salud Uninorte. 2017; 33(3):12-18
13. Salem E, El-Garawani I, Allam H, El-Aal BA, Hegazy M. Genotoxic effects of occupational exposure to benzene in gasoline station workers. Ind Health. 2018; 7; 56(2):132-140.
14. Mcneely M. Métodos y diagnósticos del laboratorio clínico. En: Sonnenwirth A, Jaret L. Función renal. Buenos Aires: Editorial Médica Panamericana; 1983. p. 459-70.
15. Müting D, Keller H, Kraus W. Quantitative colorimetric determination of free phenols in serum and urine of healthy adults using modified diazo-reactions. Clin Chim Acta. 1970; 27(1):177-80.
16. Fenech M, Morley A. Measurement of micronuclei in lymphocytes. Mut Res.1985; 147:29-36.
17. Agencia para Sustancias Tóxicas y el Registro de Enfermedades (ATSDR). División de Toxicología y Medicina Ambiental. Resumen de salud pública. Benceno [Internet] [citado 10 May 2019]. Disponible en: http://www.atsdr.cdc.gov/es/
18. American Conference of Governmental Industrial Hygienists. Biological Exposure Indices (BIEs). Cincinnati, Ohio: ACGIH; 2018.
19. Zuluaga M, Valencia A, Ortiz I. Efecto genotóxico y mutagénico de contaminantes atmosféricos. Medicina UPB. 2009; 28:33-41.
20. Partanen T, Monge P, Wesseling C. Causes and preven-tion of occupational cancer. Acta Médica Costarricense. 2009; 51:33-44.
21. Negrin J, Aular Y, Fernández Y, Piñero S, Romero G. Ácido trans, trans mucónico y perfil hepático, hematológico y renal en trabajadores expuestos a benceno.2014; 22(2):121-128
22. Pérez H. Evolución de la exposición a solventes orgánicos(BTXs) en trabajadores de estaciones de servicio de Sincelejo.(Trabajo de maestría) Universidad de Sucre:Colombia;2018
23. Stenehjem JS, Kjærheim K, Bråtveit M , Samuelsen O, Barone-Adesi ,F Rothman ,N . Benzene exposure and risk of lymphohaematopoietic cancers in 25 000 offshore oil industry workers. Br J Cancer. 2015;112(9):1603-12
24. Cárdenas-Bustamante O, Varona-Uribe M, Patiño-Florez R, Groot-Restrepo H, Sicard-Suárez D, Tórres-Carvajal M, Pardo-Pardo D. Exposición a solventes orgánicos y efectos genotóxicos en trabajadores de fábricas de pinturas en Bogotá. Rev Salud Pública.2007; 9 (2):275-288.
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