Mus musculus: an experimental model for Deiodinase (DIO3) and Transthyretin (TTR) expression during placental development

Authors

DOI:

https://doi.org/10.18041/1900-3803/entramado.1.6538

Keywords:

Animal Models, iodothyronine deiodinase type III, Placenta, Prealbumin, Pregnancy, Thyroid Hormones

Abstract

Introduction: Correct functioning of hypothalamic-pituitary-thyroid axis is essential for embryonic-fetal growth and development, as it is involved in tissue differentiation, brain and somatic development, bone maturation and metabolic regulation. Maternal thyroid hormones passage to the fetus through the placenta depends on transmembrane transporters, deiodinase enzymes (DIO2 and DIO3) and carrier proteins (TTR). Objective: Identify DIO3 and TTR expression within placental layers of Mus musculus E10.5, E12.5 and E14.5. Methods: Placental structure, DIO3 and TTR expression were evaluated using histochemistry and immunofluorescence techniques. Results: We found that the three placental layers, labyrinth zone, junctional zone, and decidua were present since E10.5. At E12.5 placental final conformation was observed. DIO3 and TTR were detected in the three stages with a predominance in the labyrinth. Conclusion: DIO3 and TTR are expressed throughout the establishment and maturation of mouse placenta. Mice are a useful tool for studying how thyroid hormones are transported from maternal to fetal circulation at the placenta.

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Author Biographies

  • Luis Felipe Falla-Zuñiga, Universidad del Valle, Cali - Colombia

    Universidad del Valle, Cali - Colombia

  • Debora Sinner, Perinatal Institute del Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio - Estados Unidos

    Assistant Professor, Perinatal Institute at Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio - USA

  • María Carolina Pustovrh, Universidad del Valle,  Cali - Colombia

    Associate Professor, Universidad del Valle, Cali - Colombia.

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2021-01-30

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Vol. 17 No. 1 (2021): Entramado

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Falla-Zuñiga, L. F., Sinner, D., Moreno-Martínez, D., Castellanos-Garzón, J. A., Salazar-Monsalve, L., & Pustovrh, M. C. (2021). Mus musculus: an experimental model for Deiodinase (DIO3) and Transthyretin (TTR) expression during placental development. Entramado, 17(1), 218-230. https://doi.org/10.18041/1900-3803/entramado.1.6538

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