Teratogenic effect of cadmium: From the developing embryo to the fetus
From The Developing Embryo To The Fetus
DOI:
https://doi.org/10.18041/2322-634X/rcso.2.2015.4898Keywords:
Cadmio, teratogénesis, carcinogénesis, desarrollo embrionarioAbstract
Cadmium is recognized as a toxic metal recognized by the United Nations Organization list, and also a potential teratogen in humans.
Objective: Of this study was to review the teratogenic effects of Cd in the human embryonic development from pre implantation, implantation and post implantation, and impact on the placenta and fetus.
Methodology: The levels of ingestion varies by country, being seafood and tobacco smoke the principal reported sources. This metal has a long half-life, ranging from 75 days to 26 years, and is associated in humans to many cancers.
Results: The teratogenic impact of cadmium in each stage of the developing embryo is clear in animal models, but not in humans.
Conclusions: In the pre-implantation phase it affects the progression from the two-cell stages to morula; in the implantation phase it affects the trophoblastic invasion; in post-implantation phase it affects organogenesis; in the placenta it decrease Zinc levels in the fetus.
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