Overlap syndrome with autoimmune hepatitis and primary biliary cholangitis

Authors

  • Harol Herrera Villalba Clínica General del Norte
  • Alcides Herrera Alvarado Clínica General del Norte
  • Fair Clavijo Tinoco Clínica General del Norte
  • Jorge Fernández Franco Clínica General del Norte
  • Ronald Maestre Serrano Universidad Libre
  • Mario Moscote Granadillo Clínica General del Norte

DOI:

https://doi.org/10.18041/2390-0512/biociencias.1.6366

Keywords:

Overlap syndrome, Autoimmune Hepatitis, Primary sclerosing cholangitis

Abstract

Introduction: The term "Overlap Syndrome" refers to one of the variant forms of autoimmune hepatitis, in which clinical and serological findings of autoimmune hepatitis are found in relation to the characteristics of certain cholestatic liver diseases such as primary biliary cholangitis (PBC) and Primary sclerosing cholangitis (PEC). Objetive: The early recognition of these variants is clinically significant from the point of view of treatment and prognosis. Methodology: A case is presented, corresponding to a female patient of 66 years of age who consulted for chronic clinical picture of generalized pruritus, and absence of dermatological lesions, with paraclinical studies that showed hypertransaminasemia and cholestatic pattern, with positivity for antimitochondrial, anti-smooth muscle and Inmunoglobulin G (IgG) with elevation of its concentrations. Conclusions: The histopathological study reported necroinflammatory activity in the absence of fibrous expansion, resulting in good prognosis, and instauration of therapeutic regimen, with UDCA, systemic corticosteroids, immunosuppressive agents, with adequate clinic response.

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References

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Published

2020-05-21

Issue

Vol. 15 No. 1 (2020): Biociencias

Section

CASE REPORTS

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How to Cite

Overlap syndrome with autoimmune hepatitis and primary biliary cholangitis. (2020). Biociencias, 15(1), 103-111. https://doi.org/10.18041/2390-0512/biociencias.1.6366

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