Major biochemical markers that act as predictors severity in patients with severe preeclampsia in ages 18 and 26 in the Niño Jesús Hospital of Barranquilla, 2014-2015

Abstract

The objective of this research was to determine which of the major biochemical markers that are part of the profile toxemic have greater association with severe pre-eclampsia in patients aged between 18 and 26 years in the Niño Jesus Hospital of Barranquilla in the period December 2014 to May 2015, is a retrospective descriptive correlational study; in this study 120 medical records of pregnant women who consulted in the Niño Jesus Hospital of Barranquilla which had pre-eclampsia in the aforementioned period were reviewed, they were classified by groups: Those that remained with a diagnosis of pre-eclampsia and patients that ended in severe pre-eclampsia. The variables analyzed were age, gestational age, blood pressure, risk factors and the development of preeclampsia, results toxemic profile (creatinine, LDH, transaminases, platelets, total, direct and indirect bilirubin, proteinuria random and within 24 hours). Toxemic profile components that had a close relationship with severe pre-eclampsia were the LDH (OR 3.35, 95% CI 0.41-26.84), platelets (OR 0.17 95% CI 0.028-1.08) and random proteinuria (OR 0.81 95% CI 0.16 -4.04). Given the general characteristics of pregnant women with severe pre-eclampsia study population the average age at presentation was 21.6 years appearing more frequently in patients aged between 18 and 20 years, most of these pregnant women in their first pregnancy (gilts); likewise the median gestational age at presentation was 36.5 weeks, with the largest group affected with gestational age between 35 and 39.6 weeks gestation, terminating pregnancy mostly surgically (cesarean). The most frequent risk factor was a family history of hypertension.