Clinic Relationship between Non-immune Jaundice and Urinary Tract Infection in Newborns

Authors

  • Carolina Andrea García Flórez Universidad Libre de Colombia
  • Ricardo León Sánchez Consuegra Universidad Libre de Colombia https://orcid.org/0000-0001-7121-2877
  • Rut Nohemi Giraldo García Universidad Libre de Colombia
  • María Camila García López Universidad Libre de Colombia
  • Sara Marcela Daza Martínez Universidad Libre de Colombia

DOI:

https://doi.org/10.18041/2390-0512/biociencias.1.11058

Keywords:

Jaundice, neonates, urinary tract infection

Abstract

Introduction: this study aims to analyze the relationship between non-immune jaundice and urinary tract infection (UTI) in full-term neonates. Additionally, it investigates the frequency of this association in jaundiced patients without fever but with evidence of UTI. The study seeks to determine if UTI is a contributing factor to neonatal jaundice and explore other potential associated factors.

Methodology: a prospective cross-sectional descriptive study was conducted using medical records of neonates who developed idiopathic jaundice within the first 15 days of life, between January 2019 and July 2021. Parametric description of the variables was performed, along with an analysis of the medical records of neonates treated at San Diego General Clinic in Barranquilla, Atlántico.

Results: females showed a predominance in the association between non-immune jaundice and UTI, accounting for 54%, compared to males at 46%. The most common age range for detecting non-immune jaundice was between 4 to 8 days of life, with Escherichia coli (E. coli) being the most frequently identified causative microorganism for UTI.

Conclusions: in neonates under 10 days of age diagnosed with jaundice requiring hospitalization for phototherapy based on Bhutani curves, UTI should be considered as part of the clinical picture or a predictive factor. Urine culture should be included in the diagnostic protocol for early detection of UTI in these neonates.

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Author Biographies

  • Carolina Andrea García Flórez , Universidad Libre de Colombia

    Médico general, Universidad Libre Seccional Barranquilla. andrea.carolinagf@gmail.com.

  • Ricardo León Sánchez Consuegra , Universidad Libre de Colombia

    Neonatólogo, Universidad Libre Seccional Barranquilla. https://orcid.org/0000-0001-7121-2877. rlsanchezc@gmail.com.

  • Rut Nohemi Giraldo García, Universidad Libre de Colombia

    Médico general, Universidad Libre Seccional Barranquilla. rutgiraldogar@gmail.com.

  • María Camila García López, Universidad Libre de Colombia

    Médico general, Universidad Libre Seccional Barranquilla. camilagarlop@gmail.com.

  • Sara Marcela Daza Martínez , Universidad Libre de Colombia

    Médico general, Universidad Libre Seccional Barranquilla. saramdazam@hotmail.es.

References

Mazzi Gonzales de Prada Eduardo. Hiperbilirrubinemia neonatal. Rev. bol. ped. [Internet]. 2005 enero [citado 2021 Nov 04]; 44( 1 ): 26-35. Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1024-06752005000100007&lng=es.

Özcan, Murat, S Ümit Sarici, Yüksel Yurdugül, Melis Akpinar, Demet Altun, Begüm Özcan, Muhittin A Serdar, and Dilek Sarici. Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections. Clinical Medicine Insights: Pediatrics. [Internet] 2017 Ene [citado 2021 Nov 04]; 11. Disponibe en: https://doi.org/10.1177/1179556517701118.

American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. [Internet]. 2004 Jul [citado 2021 Nov 04]; 114 (1): 297-316. Disponible en: https://pubmed.ncbi.nlm.nih.gov/15231951/

Amiri, F. B., Tavasoli, S., Borumandnia, N., & Taheri, M. Factors Affecting Prevalence of Urinary Tract Infection in Neonates with Unexplained Hyperbilirubinemia: A Systematic Review and Meta-Analysis Study in Iran. Iranian Journal of Public Health. [Internet] 2021 [citado 2021 Nov 04]; 50(7): 1311-1323. Disponible en: https://doi.org/10.18502/ijph.v50i7.6617

Akbari, A., Sajadian, H., Hosseini, S., & Amiresmaili, S. Prevalence of Urinary Tract Infection in Newborns with Prolonged Jaundice in Bam City, Iran (2015). Journal of Occupational Health and Epidemiology [Internet] 2020 [citado 2021 Nov 04]; 9(4): 225-230. Disponible en: https://doi.org/10.52547/johe.9.4.225

National Institute for Health and Care Excellence (NICE). Jaundice in newborn babies under 28 days. Clinical guideline [cg98]. NICE. [Internet]. 2010 May [citado 2021 Nov 04] Disponible en: https://www.nice.org.uk/guidance/cg98

Aloy Figueras, J, Miguélez, Rodriguez, J.M. Ictericia Neonatal. Protocolos Diagnóstico Terapéuticos de la AEP: Neonatología [Internet] 2016 [citado 2021 Nov 04] vol.38: 373-383. Disponible en: https://www.aeped.es/sites/default/files/documentos/38.pdf

Galíndez-González A, Carrera-Benavides S, Díaz-Jiménez A, Martínez-Burbano M. Factores predisponentes para ictericia neonatal en los pacientes egresados de la UCI neonatal, Hospital Infantil los Ángeles de Pasto. US [Internet]. 6dic.2017 [citado 4nov.2021];19(3):352-8. Disponible en: https://revistas.udenar.edu.co/index.php/usalud/article/view/3466

J. Campistol, H. Galvez, A. García Cazorla, I. Málaga, M. Iriondo, V. Cusí. Disfunción neurológica inducida por bilirrubina. Neurología. [Internet] 2012 [citado 2021 Nov 04]; 27(4): 202-211. Disponible en: https://doi.org/10.1016/j.nrl.2010.03.013.

HERNÁNDEZ CH MARTA, SCHMIDT C M. IGNACIA, HUETE L ISIDRO. Kernicterus (bilirubin encephalopathy): case reports. Rev. chil. pediatr. [Internet]. 2013 Dec [cited 2021 Nov 04] ; 84( 6 ): 659-666. Available from: http://dx.doi.org/10.4067/S0370-41062013000600009.

Vásquez, Rodrigo, Martínez, María. Guías de práctica clínica basadas en la evidencia - Ictericia neonatal. [Internet] Colombia: PROYECTO ISS-ASCOFAME; 2015 [citado 2021 Nov 04] Disponible en: https://www.yumpu.com/es/document/read/34378940/ictericia-neonatalpdf-colombiana-de-salud

Robert M. Kliegman,Nathan J. Blum,Samir S. Shah,Joseph W. St Geme,Robert C. Tasker,Karen M. Wilson,Richard E. Behrma. Nelson. Tratado de Pediatría. 21st ed. España. Elsevier; 2020

Mhairi G. MacDonald; Mary M.K. Seshia. AVERY, Gordon. Neonatología. Diagnóstico y tratamiento del recién nacido 7th Ed. España: Wolters Kluwer; 2017

Mª Purificación Ventura Faci*, Mª Pilar Samper Villagrasa. Infección urinaria en el recién nacido. Protocolos Diagnóstico Terapéuticos de la AEP: Neonatología [Internet] 2018 [citado 2021 Nov 04] 512 - 518. Disponible en: https://www.aeped.es/sites/default/files/documentos/53.pdf

Ardila, M., Rojas, M., Santisteban, G., Gamero, A., & Torres, A. Infección urinaria en pediatría. Revista Repertorio De Medicina Y Cirugía [Internet] 2015 [citado 2021 Nov 04]. Disponible en: https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/632

Roi Piñeiro Pérez, María José Cilleruelo Ortega, Josefa Ares Álvarez, Fernando Baquero-Artigao, Juan Carlos Silva Rico, Roberto Velasco Zúñiga, Leticia Martínez Campos, Begoña Carazo Gallego, Antonio José Conejo Fernández, Cristina Calvo, Santiago Alfayate Miguélez, Alicia Berghezan Suárez, César García Vera, Juan José García García, Marisa Herreros, Carlos Rodrigo Gonzalo de Liria. Recomendaciones sobre el diagnóstico y tratamiento de la infección urinaria. Anales de Pediatría [Internet] 2019 [citado 2021 Nov 04] Disponible en: https://doi.org/10.1016/j.anpedi.2019.02.009.

Shahian M, Rashtian P, Kalani M. Unexplained neonatal jaundice as an early diagnostic sign of urinary tract infection. Int J Infect Dis [Internet] 2012 [citado 2021 Dic 06]; 16(7): 487-490. Disponible en: https://www.ijidonline.com/article/S1201-9712(12)00070-7/fulltext

Mutlu, Mehmet., Cayir, Yasemin., Aslan, Yakup. Urinary tract infections in neonates with jaundie in their first two weeks of life. World J Pediatr [Internet] 2014 [citado 2021 Dic 03]; 10 (2): 164-167. Disponible en: https://link.springer.com/article/10.1007/s12519-013-0433-1

Garcia FJ, Nager AL. Jaundice as an early diagnostic sign of urinary tract infection in infancy. Pediatrics [Internet] 2002 [citado 2021 Dic 06]; 109 (5): 846–851. Disponible en: https://publications.aap.org/pediatrics/article-abstract/109/5/846/64282/Jaundice-as-an-Early-Diagnostic-Sign-of-Urinary?redirectedFrom=fulltext

Bilgen H, Ozek E, Unver T, Biyikli N, Alpay H, Cebeci D. Urinary tract infection and hyperbilirubinemia. Turk J Pediatr. [Internet] 2006 [citado 2021 Dic 06]; 48(1):51-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16562786/

Bahat Ozdogan E, Mutlu M, Camlar SA, Bayramoglu G, Kader S, Aslan Y. Urinary tract infections in neonates with unexplained pathological indirect hyperbilirubinemia: Prevalence and significance. Pediatr Neonatol. [Internet] 2018 [citado 2021 Dic 06]; 59(3):305-309. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29150336/

Baz, A., El-Agamy, O., & Ibrahim, A. M. Incidence of urinary tract infection in neonates with significant indirect Hyperbilirubinemia of unknown etiology: case-control study. Italian journal of pediatrics, [Internet] 2021 [citado 2021 Dic 06]; 47(1), 35. Disponible en: https://doi.org/10.1186/s13052-021-00982-0

Liu J, Qu J, Chen H, Ge P, Jiang Y, Xu C, Chen H, Shang D, Zhang G. The pathogenesis of renal injury in obstructive jaundice: A review of underlying mechanisms, inducible agents and therapeutic strategies. Pharmacol Res. [Internet] 2021 [citado 2021 Dic 06]; 163. Disponible en: https://www.sciencedirect.com/science/article/pii/S1043661820316194

Published

2023-06-15

Issue

Section

ARTICLE OF SCIENTIFIC AND TECHNOLOGICAL RESEARCH

How to Cite

Clinic Relationship between Non-immune Jaundice and Urinary Tract Infection in Newborns. (2023). Biociencias, 18(1). https://doi.org/10.18041/2390-0512/biociencias.1.11058

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