Matriz extracelular de la submucosa de intestino delgado (mec- sid; sid) como biomaterial versátil en medicina regenerativa basada en ingeniería de tejidos
Autores/as
- Duverney Gaviria Arias Universidad Libre
- Víctor Manuel Castaño Biotriskel
- Lina Janeth Arteaga Valencia ESE Hospital Universitario San Jorge
Palabras clave:
Reparación de tejidos, matriz extracelular, Biomateriales, Ingeniería de tejidos, Propiedades fisicoquímicasResumen
Durante las últimas décadas, la submucosa del intestino delgado (SID), una matriz extracelular descelularizada (MEC) de origen natural, ha atraído atención en la reparación de tejidos porque puede proporcionar abundantes factores bioactivos y un microambiente biomimético de tres dimensiones para inducir las funciones celulares deseadas.
En este artículo se revisan las últimas investigaciones sobre SID, que se centran en los siguientes aspectos: superioridad principal como una notable bioactividad, baja inmunogenicidad, reabsorbibilidad y capacidad de recelularización. Se reporta como la adhesión, proliferación, migración y diferenciación de las células se ve influenciada cuando son depositadas sobre este soporte, debido a sus características. Se presenta el gran potencial de este biomaterial para resolver los problemas de cuello de botella que se encuentran en la reparación de varios tejidos, convirtiéndola en un excelente biomaterial para uso en medicina regenerativa basada en ingeniería de tejidos.
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Referencias
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