Megaloblastic anemia: a diagnostic challenge for the physician. series of clinical cases

Authors

  • Marco Gómez Barrios Clínica General del Norte
  • David Castro S Clínica General del Norte

DOI:

https://doi.org/10.18041/2390-0512/biociencias.1.7844

Keywords:

Macrocytosis, megaloblastic anemia, pernicious anemia, myelodysplastic syndrome

Abstract

We describe the clinical and laboratory characteristics of 3 patients who had megaloblastic anemia with different etiologies. Two cases with a diagnosis of pernicious anemia, one of them related to an infection by Helicobacter pylori and the second one mediated by autoimmune mechanisms; In the last patient, megaloblastic anemia was the presenting form of a myelodysplastic syndrome. Subsequently, we present a common sense approach to the first contact with the patient with megaloblastic anemia and the therapeutic bases according to current evidence for their underlying pathology

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References

Hernández García MT, Escribano L. Anemias megaloblásticas. 4º ed. Manual

práctico de hematología clínica: Antares; 2012.

Hernández García MT, Hernández Nieto. Anemias. Generalidades. 4º ed. Manual práctico de hematología clínica: Antares; 2012.

Schrier, SL. Etiology and clinical manifestations of vitamin B12 and folate deficiency. Macrocytosis. Diagnosis and treatment of vitamin B12 and folate deficiency. In: UpToDate, Mentzer, WC (Ed), UpToDate, Waltham, MA, 2014.

Woessner Casas S, Florensa Brichs L. Anemias megaloblásticas. 4º ed. La citología óptica en el diagnóstico hematológico: Acción Médica, S.A; 2006.

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Published

2021-05-30 — Updated on 2023-05-16

Issue

Vol. 16 No. 1 (2021): Biociencias

Section

CASE REPORTS

License

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