Efectiveness and safety of adrenaline versus nebulized salbutamol in patients with acute bronchiolitis. Barranquilla, January of 2012- April of 2013

Abstract

Objective: Determine the efficacy and safety management with adrenaline versus albuterol nebulized in pediatric patients diagnosed with acute bronchiolitis in Hospital Niño Jesus and Barranquilla district hospitals, during Janu- ary 2012 to April 2013. Materials and Methods: Controlled clinical trial in patients with acute bronchiolitis; nonrandom convenience sample (50 patients per group). Patients were treated with a scheme of 3 sprays every 20 minutes with 1 % adrenaline (0.5 mg / kg adrenaline group) or 0.5 % salbutamol (0.15 mg / kg, salbutamol group). Before and after the application of therapeutic scheme evaluation was performed. Evaluations were done at 30 and 60 minutes, applying scale Tal. Results: Upon admission, patients receiving adrenaline were classified as moderate and severe 88 % 12 %; after 60 minutes were classified as mild 48 %, moderate 50 %, severe 2 % (control 60 minutes OR = 0.67, CI = 0.56 to 0.78, p <0.00001); patients receiving scheme with salbutamol, were classified as moderate income 92 % and 8 % severe, at 60 minutes were classified as mild 22 %, moderate 74 % and severe 4 % (control 60 minutes OR = 0.57, CI = 0.47 to 0.67, p = 0.0003). Conclusions: Nebulized adrenaline is more effective than nebulized salbutamol in the management of acute bron- chiolitis in population under 1 year old.