Effectiveness of radiotherapy vs radiotherapy-chemotherapy in patients with locally advanced cervical cancer. Barranquilla (Colombia)
Keywords:
Radiotherapy, Chemotherapy, Uterine cervical cancerAbstract
Objective: Determine effectiveness of radiotherapy vs radiotherapy-chemotherapy in patients with locally ad- vanced cervical cancer. Barranquilla (Colombia). Materials and Methods: Comparative analytical study conducted in patients diagnosed with locally advanced cervical cancer in two private hospitals of Barranquilla, using simple sampling Epidat, a significant sample of 50 patients per group was considered. Radiotherapy Group (RT): Radiation therapy in the range of 50 Gy for 5 weeks; Radiotherapy-Chemotherapy Group (RT-CT): radiation in the range of 50 Gy for 5 weeks + cisplatin 40 mg/m² / week for 6 weeks. Epi-Info 3.5.1 was used to tabulate. Significance level was <0.05. Results: Patients of 51 years old or more were more frequent in the two study groups, in the RT group, the average age at onset of sexual activity was 18.1 ± 3.6 years; in the RT-CT group, the average was 17.1 ± 2.6 years, 52% in the RT group and 54 % in the RT-CT group reported more than 3 sexual partners. Complete response to therapy was more frequent in the RT-CT patients (28 %) compared with 14 % in the RT (value p = 0.08), adverse events were more frequent in the RT-CT group (90 %, p = 0.001). Conclusion: No significant difference was found in efficacy between radiotherapy and radiotherapy-chemothera- py used in patients with locally advanced cervical cancer.
Downloads
References
2.Borrero M. Actualización en citología cervi- covaginal. En: XI Curso de Actualización en Obstetricia y Ginecología. Universidad de Antioquia. 2003; 41-50.
3.Lazcano-Ponce E, Alonso P, Ruiz-Moreno JA, Hernandez-Avila M. Recommendations for cervical cancer screening programs in de- veloping countries. The need for equity and technological development. Salud Publica Mex. 2003; 45 Suppl 3:S449-62.
4.Globocan. database. Cancer incidence, mor- tality and prevalence worldwide [página en Internet]. [Actualizado 15 oct 2012; citado 15 nov 2012]. Disponible en: http://www- dep.iarc.fr/globocan/database.htm
5.Waggoner SE. Cervical cancer. Lancet. 2003; 361:2217-25.
6.Secretaría de Salud del Atlántico; Registro Poblacional de Cáncer; 2011 [página en In- ternet]. [Actualizado 15 mar 2013; citado 20 mar 2013]. Disponible en: www.atlantico. gov.co
7.Pinilla E, Uribe J, González G. Cáncer de cér- vix IB. Análisis de 110 casos. Rev Colomb Obstet Ginecol. 1988; 39:186-90.
8.Landoni F, Maneo A, Colombo A, Placa F, Mi- lani R, Perego P, et al. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cáncer. Lancet. 1997; 350:535- 40.
9.Barillot I, Horiot JC, Pigneux J, Schraub S, Pourquier H, et al. Carcinoma of the intact uterine cervix treated with radiotherapy alo- ne: A French cooperative Study: Update and analysis of prognostic factors. Int J Radiat Oncol Biol Phys. 1997; (5):969-78.
10.Marsiglia H. Nuevos abordajes del cáncer de cérvix localmente avanzado. Rev Colombiana de Cancerología. 2002; 6(1):20-2.
11.Thoms WW Jr, Eifel PJ, Smith TL, Morris M, Delclos L, Wharton JT, et al. Bulky endocer- vical carcinoma: A 23-year experience. Int J Radiat Oncol Biol Phys. 1992; 23(3):491-9.
12.Pérez CA, Grigsby PW, Chao CKS. Chemothe- rapy and irradiation in locally advanced squa- mous cell carcinoma of the uterine cervix: A review. Semin Radiat Oncol 1997; 7(Suppl 2):45-65.
13.Thigpen JT. If and when 2 the role of chemo- therapy it locally advanced carcinoma of the cervix. Ann Med 1998; 9(9): 933-5.
14.García-Soto G, Pachón-Rincón J, Meneses- Cubides R, Zuleta-Tobón J. Cáncer de cuello uterino: experiencia durante un periodo de seis años en un hospital universitario colom- biano. Rev Colomb Obstet Ginecol. 2007; 58.
15.International Collaboration of Epidemiologi- cal Studies of Cervical Cancer. Cervical car- cinoma and reproductive factors: collabora- tive reanalysis of individual data on 16.563 women with cervical carcinoma and 33.542 women without cervical carcinoma from 25 epidemiological studies. Int J Cancer. 2006 Sep 1; 119(5):1108-24.
