Cervical cancer and HPV
Molecular aspects
Keywords:
Uterine cervical neoplasms, Papillomavirus infections, Genes p53, Genetic polymorphismAbstract
The cervical cancer is a major public health problem. In Latin America and in the countries of the Caribbean, the incidence and mortality rate of this disease are the highest worldwide. Colombian population presents high risk because the annual incidence of this pathology ranges from 44 to 88 per 100.000 women. Human papillomavirus (HPV) infection is considered a risk factor to suffer cervical cancer. There are also genetic factors that predispose to the development of cancer prior infection. Taking into account that a small proportion of infected patients do not present pre malignant lesions, knowledge of genetic and environmental factors supplies a greater understand- ing of the mechanisms involved in cancer, which will have many clinical implications that will facilitate the early detection of susceptible people.
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References
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