Plasma Cell Leukemia: An Infrequent Cause of Chest Pain: A Case Report

Authors

  • Cristina Paola Zurique Sánchez Fundación Universitaria de Ciencias de la Salud
  • Natalia Carolina González Redondo Universidad de Cartagena
  • Nicole Chamorro Guzmán Fundación Universitaria Sanitas
  • Alejandra Vergara Schotborgh Universidad de Cartagena
  • Cristian Muñoz Gómez Universidad del Cauca
  • Carlos Amell Menco Clínica IMAT Oncomedica
  • Lievi Geovanni Correa Negrete Universidad del Cauca

DOI:

https://doi.org/10.18041/2390-0512/biociencias.1.13149

Keywords:

chest pain, neoplasia, plasma cell leukemia

Abstract

Plasma cell leukemia is one of the rarest hematological malignancies worldwide. We present the case of a 45-year-old male patient who presented to the emergency department with chest pain as a clinical manifestation of leukostasis. Peripheral blood flow cytometry showed 37.80% pathological plasma cells, and a bone marrow biopsy documented infiltration of 50.68% pathological plasma cells. Therefore, plasma cell leukemia was diagnosed and a high-intensity chemotherapy regimen with the DCEP protocol was prescribed. This case is described is not only a rare hemato-oncological malignancy but also an uncommon cause of chest pain in adults. This case highlights the need for a thorough review, including the complete blood count, during the diagnostic approach to all chest pain cases in the emergency department.

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References

1. Gowin K, Skerget S, Keats JJ, Mikhael J, Cowan AJ. Plasma cell leukemia: A review of the molecular classification, diagnosis, and evidenced-based treatment. Leuk Res. 2021;111:106687. DOI: 10.1016/j.leukres.2021.106687.

2. Gundesen MT, Lund T, Moeller HEH, Abildgaard N. Plasma Cell Leukemia: Definition, Presentation, and Treatment. Curr Oncol Rep. 2019;21(1):8. DOI: 10.1007/s11912-019-0754-x.

3. Jung SH, Lee JJ. Update on primary plasma cell leukemia. Blood Res. 2022;57(S1):62-66. DOI: 10.5045/br.2022.2022033.

4. Peral-Rodríguez R, Estévez-González F, García-Montoya L. Motivos de ingreso más frecuentes y variables relacionadas en la sala de reanimación de urgencias. Enfermería clínica. 2009;19(3):136 – 40. DOI: 10.1016/j.enfcli.2009.02.005.

5. Foy AJ, Filippone L. Chest pain evaluation in the emergency department. Med Clin N Am. 2015;99(4)835-47.

6. Bañol-Betancur J-I, Martínez-Sánchez L-M, Rodríguez-Gázquez M-A, Bahamonde-Olaya E, Gutiérrez-Tamayo A-M, Jaramillo-Jaramillo L-I et al. Caracterización del dolor torácico en pacientes que consultan al Servicio de Urgencias de una institución de salud de alto nivel de complejidad, en el periodo 2014-2015, en Medellín, Colombia. Rev. Soc. Esp. Dolor. 2017;24(6):288-293. DOI: 10.20986/resed.2017.3571/2017.

7. Artigas O. Dolor torácico en los servicios de urgencias. Med Int. 2002; 40(2):40-49.

8. Cooper A, Hodgkinson DW, Oliver RM. Chest pain in the emergency department. Hospital medicine.2000;61(3):178-183. DOI: 10.12968/hosp.2000.61.3.1296.

9. Kontos MC, de Lemos JA, Deitelzweig SB, Diercks DB, Gore MO, Hess EP et al. ACC Expert Consensus Decision Pathway on the Evaluation and Disposition of Acute Chest Pain in the Emergency Department: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2022;80(20):1925-1960. DOI:

10.1016/j.jacc.2024.07.009.

10. Kontos MC, Diercks DB, Kirk JD. Emergency department and office-based evaluation of patients with chest pain. Mayo Clin Proc. 2010;85(3):284-99. DOI: 10.4065/mcp.2009.0560.

11. Rajkumar V. Multiple myeloma: 2022 update on diagnosis, risk stratification, and management. Am J Hematol. 2022;97(8):1086-1107. DOI: 10.1002/ajh.26590.

12. Fernández de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH et al. (International Myeloma Working Group). Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia. 2013;27(4):780-91. DOI: 10.1038/leu.2012.336.

13. Yan W, Fan H, Xu J, Liu J, Li L, Du C et al. The clinical characteristics and prognosis of patients with primary plasma cell leukemia (pPCL) according to the new IMWG definition criteria. Leuk Lymphoma. 2022;63(12):2955-2964. DOI: 10.1080/10428194.2022.2098290.

14. Fernández de Larrea C, Kyle R, Rosiñol L, Paiva B, Engelhardt M, Usmani S et al. Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage. Blood Cancer J. 2021; 11(12):192. DOI: 10.1038/s41408-021-00587-0.

15. Mina R, D'Agostino M, Cerrato C, Gay F, Palumbo A. Plasma cell leukemia: update on biology and therapy. Leuk Lymphoma. 2017;58(7):1538-1547. DOI: 10.1080/10428194.2016.1250263.

16. Tiedemann RE, González-Paz N, Kyle RA, Santana-Dávila R, Price-Troska T, Van Wier SA et al. Genetic aberrations and survival in plasma cell leukemia. Leukemia. 2008;22(5):1044-52. DOI: 10.1038/leu.2008.4.

17. Khosravi S. Leucemia de células plasmáticas: variante rara del mieloma múltiple. An Med. Interna. 2005; 22(11):4-9.

18. Amarilla I, Caballero C. Leucemia de células plasmáticas: a propósito de un caso. Revista Electrónica de Portales Médicos. 2022; 17(19): 790.

19. Yánez J, Saldias V, Díaz O, Saldias F. Compromiso pleural en la leucemia de células plasmáticas: Reporte de un caso. Rev Chil Enf Respir. 2008; 24: 304-308. DOI: 10.4067/S0717-73482008000400005.

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Published

2025-12-06

Issue

Volume 20 Issue 1 2025

Section

CASE REPORTS

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