INFECCIÓN URINARIA GESTACIONAL COMO FUENTE DE COMPLICACIONES PERINATALES Y PUERPERALES
DOI:
https://doi.org/10.18041/2390-0512/biociencias.1.5341Palabras clave:
Infección, Cistitis, Pielonefritis, Bacteriuria, Recién nacidoResumen
La infección en la mujer gestante ha demostrado ser una situación de alto riesgo, para el desarrollo y correcto desenlace de la gestación. La proliferación de los diferentes
patógenos que se asientan o llegan a colonizar el tracto urinario, sea que se conviertan en una entidad clínica sintomática o no, pueden terminar en complicaciones evitables para el binomio madre-hijo. Con la siguiente revisión se pretende considerar la evidencia disponible acerca de las características y participación de la infección urinaria en la génesis de complicaciones perinatales y puerperales.
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Referencias
1. Ailes EC, Summers AD, Tran EL, et al. Antibiotics Dispensed to Privately Insured Pregnant Women with Urinary Tract Infections — United States. MMWR Morb
Mortal Wkly Rep 2018;67:18–22.
2. Quiroga G, Robles R, Ruelas A, Gómez A. Bacteriuria asintomática en mujeres embarazadas una amenaza subestimada. Rev Med Inst Mex Seguro Soc 2007;45
(2):169-172
3. Glaser AP, Schaefer AJ. Urinary tract infection and bacteriuria in pregnancy. Urol Clin North Am. 2015 Nov;42(4):547-60
4. Szweda H, Marcin J .Urinary tract infections during pregnancy an updated overview. Dev period med. 2016;4:263-272
5. Haider G, Zehra N, Munir A, Haidar A. Risk factors of UTI in pregnancy. J Pak Med Assoc. 2010;60(3):213–6
6. Gessese YA, Damessa DL, Amare MM, Bahta YH, Shifera AD, Tasew FS, et al.Urinary pathogenic bacterial profile, antibiogram of isolates and associated risk
factors among pregnant women in Ambo town, Central Ethiopia: a cross-sectional study. Antimicrob Resist Infect Control. 2017 Dec 29;6:132
7. Vallejos C, López M, Enriquez M, Valverde B. Prevalencia de infecciones de vías urinarias en embarazadas atendidas en el Hospital Universitario de Puebla. Enf Inf
Microbiol 2010;30 (4): 118-122
8. López JL, Montoya YM, Berbesi DY. Risk factors associated with acute pyelonephritis in pregnant women , from third-party payer institutions in Colombia, between 2008 and 2012. Rev Colomb Obstet Ginecol [Internet]. 2014; 65(4): 317-322
9. Hillebrand L, Harmanli OH, Whiteman V, Khandelwal M. Urinary tract infections in pregnant women with bacterial vaginosis. Am J Obstet Gynecol, 2002; 186, 916-
917
10. Badran YA, El-Kashef TA, Abdelaziz AS, Ali MM. Impact of genital hygiene and sexual activity on urinary tract infection during pregnancy. Urol Ann 2015;7:78-81.
11. Schneeberger C, Erwich JJ, Van Den Heuvel E, Mol B, Ott A, Geerlings SE. Asymptomatic bacteriuria and urinary tract infection in pregnant women with and without diabetes: Cohort study. Eur J Obstet Gynecol in press 2018 (N. del T.: En español: En prensa)
12. Lumbiganon P, Laopaiboon M, Thinkhamrop J. Screening and treating asymptomatic bacteriuria in pregnancy. Curr Opin Obstet Gynecol. 2010;22:95-9.
13. Smaill F. Asymptomatic bacteriuria in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2007 Jun;21(3):439-50
14. Geerlings SE. Clinical Presentations and Epidemiology of Urinary Tract Infections. Microbiol Spectr. 2016 Oct;4(5)
15. Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM, et al. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis Off Publ Infect Dis Soc Am. 2005;40:643-54.
16. Martínez E, Osorio J, Delgado J, Esparza G, Motoa G, Blanco VM, et al. Infecciones del tracto urinario bajo en adultos y embarazadas: Consenso para el
manejo empírico. Infectio.2013;17:122-35.
17. Gilbert NM, O’brien VP, Hultgren S, Macones G, Lewis WG, Lewis AL. Urinary Tract Infection as a Preventable Cause of Pregnancy Complications: Opportunities,
Challenges, and a Global Call to Action. Glob Adv Health Med. 2013 Sep;2(5):59-69.
18. Nicolle LE. Asymptomatic bacteriuria: when to screen and when to treat. Infect DisClin N Am 17 2003; 367–394
19. Kim SJ, Parikh P, King AN, Marnach ML. Asymptomatic bacteriuria in pregnancy complicated by pyelonephritis requiring nephrectomy. Case Reports in Obstetrics
and Gynecology, vol. 2018, Article ID 8924823, 4 pages
20. Fátima N, Ishrat S. Frecuency and risk factors of asintomatic bacteriuria during pregnancy. J Coll Physicians Surg Pak. 2006 Apr;16(4):273-5.
21. Matuszkiewicz-Rowińska J, Małyszko J, Wieliczko M. Urinary tract infections in pregnancy: old and new unresolved diagnostic and therapeutic problems. Arch Med
Sci. 2015 Mar 16;11(1):67-77
22. Jido TA. Urinary tract infections in pregnancy: Evaluation of diagnostic framework. Saudi J Kidney Dis Transpl 2014;25:85-90
23. Etminan-Bakhsh M, Tadi S, Darabi R. Asymptomatic bacteriuria in pregnant women attending Boo-Ali Hospital Tehran Iran: Urine analysis vs. urine culture.
Electronic physician 2017; 9(11): 5760-5763.
24. Gomi H, Goto Y, Laopaiboon M, Usui R, Mori R. Routine blood cultures in the management of pyelonephritis in pregnancy for improving outcomes. Cochrane
Database of Systematic Reviews 2015, Issue 2. Art. No.: CD009216
25. Reyes A, Gómez A, Rodríguez JA. Validez del parcial de orina y el Gram en el diagnóstico de infección del tracto urinario en el embarazo. Hospital Simón Bolívar,
Bogotá, Colombia, 2009-2010. Rev Col Obs Gin 2013;64(1), 53–59.
26. Estrada A, Figueroa R, Villagrana R. Infección de vías urinarias en la mujer embarazada. Importancia del escrutinio de bacteriuria asintomática durante la
gestación. Perinatol Reprod Hum 2010; 24 (3):182-186
27. Feitosa DCA, Silva MG, Parada CMGL. Accuracy of simple urine tests for diagnosis of urinary tract infections in low-risk pregnant women. Rev Latino-am
Enfermagem 2009; 17(4):507-13
28. Angelescu K, Nussbaumer-Streit B, Sieben W, Scheibler F, Gartlehner G. Benefits and harms of screening for and treatment of asymptomatic bacteriuria in pregnancy:
a systematic review. BMC Pregnancy and Childbirth 2016;16:336
29. Dutch Society for Obstetrics and Gynaecology. NVOG guideline: urinary tract infections during pregnancy. 2011
30. Alós JI, Andreu A, Arribas L, Cabero L, De Cueto M, López J et al. Prevención de la infección perinatal por estreptococo del grupo B. Recomendaciones españolas.
Actualización 2012. Documento de consenso SEIMC/SEGO/SEN/SEQ/SEMFYC. Enferm Infecc Microbiol Clin. 2013;31(3):159–172.
31. Smaill FM, Vazquez JC. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database Syst Rev. 2015;8(8)
32. Kazemier BM, Koningstein FN, Schneeberger C, Ott A, Bossuyt PM, de Miranda E, et al. Maternal and neonatal consequences of treated and untreated asymptomatic
bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial. The Lancet Infectious diseases. 2015;15(11):1324–33
33. Farkash E, Weintraub AY, Sergienko R, Wiznitzer A, Zlotnik A, Sheiner E. Acute antepartum pyelonephritis in pregnancy: a critical analysis of risk factors and
outcomes. Eur J Obstet Gynecol Reprod Biol. 2012 May;162 (1):24-7.
34. Petry CJ, Ong KK, Hughes IA, Acerini CL, Dunger DB. Associations between bacterial infections and blood pressure in pregnancy. Pregnancy Hypertens. 2017
Oct;10:202-206
35. Easter SR, Cantonwine DE, Zera CA, Lim K, Parry S, McElrath T. Urinary tract infection during pregnancy, angiogenic factor profiles, and risk of preeclampsia. Am
J Obstet Gynecol 2016;214:387.e1-7.
36. Liu J, Chiu F, Liu Y, Chen S, Chan H, Yang J et al. Antepartum urinary tract infection and postpartum depression in Taiwan – a nationwide population-based
study. BMC Pregnancy and Childbirth 2018;18:79
37. Bolton M, Horvath DJ Jr, Li B, Cortado H, Newsom D, White P et al. Intrauterine Growth Restriction Is a Direct Consequence of Localized Maternal Uropathogenic
Escherichia coli Cystitis. PLoS ONE 7(3): e33897.
38. Leviton A, Allred EN, Kuban KC, O'Shea TM, Paneth N, Onderdonk AB et al. The Development of Extremely Preterm Infants Born to Women Who Had
Genitourinary Infections During Pregnancy. Am J Epidemiol. 2016 Jan 1;183(1):28-35.
39. Kapaya H, Williams R, Elton G, Anumba D. Can Obstetric Risk Factors Predict Fetal Acidaemia at Birth? A Retrospective Case-Control Study. Journal of
Pregnancy, 2018, 1-8
40. Howley MM, Feldkamp ML, Papadopoulos EA, Fisher SC, Arnold KE, Browne ML. Maternal genitourinary infections and risk of birth defects in the National Birth
Defects Prevention Study. Birth Defects Res. 2018 Nov 15;110(19):1443-1454.
41. Ailes EC, Gilboa SM, Gill SK, Broussard CS, Crider KS, Berry RJ. Association between Antibiotic Use among Pregnant Women with Urinary Tract Infections in
the First Trimester and Birth Defects. National Birth Defects Prevention Study 1997 to 2011. Birth Defects Res A Clin Mol Teratol. 2016 Nov;106(11):940-949.
42. Verani JR, McGee L, Schrag SJ. Centers for Disease Control and Prevention: Prevention of Perinatal Group B Streptococcal Disease: Revised Guidelines from
CDC, 2010. MMWR Recomm Rep. 2010 Nov 19;59(RR-10):1-36
43. Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. The Lancet, 2017 Oct 14;390(10104):1770-1780.
44. Fichorova RN, Beatty N, Sassi RRS, Yamamoto HS, Allred EN, Leviton A, et al.Systemic inflammation in the extremely low gestational age newborn following
maternal genitourinary infections. Am J Reprod Immunol 2015; 73: 162–174
45. Smaill F, Vazquez JC. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database Syst Rev. 2007;2(2).
46. Pavón NJ. Diagnóstico y tratamiento de infección de las vías urinarias en embarazadas que acuden a Emergencia y consulta externa del Hospital Bertha
Calderón Roque en Managua, Nicaragua. Perinatol Reprod Hum 2013; 27 (1): 15-20
47. Artero A, Alberola J, Eiros JM, Nogueira JM, Cano A. Pyelonephritis in pregnancy. How adequate is empirical treatment ?. Rev Esp Quimioter. 2013 Mar;26(1):30-3.
48. Herrera M, Gómez M. Resistencia bacteriana en urocultivos de una población de embarazadas de control prenatal en Bogotá junio 2013 – junio 2015. Biociencias,
13(2), 111-124.
49. Vazquez JC, Abalos E. Treatments for symptomatic urinary tract infections during pregnancy. Cochrane Database Syst Rev. 2011 Jan 19;(1):CD002256.
50. Ghouri F, Hollywood A, Ryan K. A systematic review of non-antibiotic measures for the prevention of urinary tract infections in pregnancy. BMC Pregnancy and
Childbirth 2018; 18:99
51. Schneeberger C, Geerlings SE, Middleton P, Crowther CA. Interventions for preventing recurrent urinary tract infection during pregnancy. Cochrane Database
Syst Rev. 2015 Jul 26;(7):CD009279.
Mortal Wkly Rep 2018;67:18–22.
2. Quiroga G, Robles R, Ruelas A, Gómez A. Bacteriuria asintomática en mujeres embarazadas una amenaza subestimada. Rev Med Inst Mex Seguro Soc 2007;45
(2):169-172
3. Glaser AP, Schaefer AJ. Urinary tract infection and bacteriuria in pregnancy. Urol Clin North Am. 2015 Nov;42(4):547-60
4. Szweda H, Marcin J .Urinary tract infections during pregnancy an updated overview. Dev period med. 2016;4:263-272
5. Haider G, Zehra N, Munir A, Haidar A. Risk factors of UTI in pregnancy. J Pak Med Assoc. 2010;60(3):213–6
6. Gessese YA, Damessa DL, Amare MM, Bahta YH, Shifera AD, Tasew FS, et al.Urinary pathogenic bacterial profile, antibiogram of isolates and associated risk
factors among pregnant women in Ambo town, Central Ethiopia: a cross-sectional study. Antimicrob Resist Infect Control. 2017 Dec 29;6:132
7. Vallejos C, López M, Enriquez M, Valverde B. Prevalencia de infecciones de vías urinarias en embarazadas atendidas en el Hospital Universitario de Puebla. Enf Inf
Microbiol 2010;30 (4): 118-122
8. López JL, Montoya YM, Berbesi DY. Risk factors associated with acute pyelonephritis in pregnant women , from third-party payer institutions in Colombia, between 2008 and 2012. Rev Colomb Obstet Ginecol [Internet]. 2014; 65(4): 317-322
9. Hillebrand L, Harmanli OH, Whiteman V, Khandelwal M. Urinary tract infections in pregnant women with bacterial vaginosis. Am J Obstet Gynecol, 2002; 186, 916-
917
10. Badran YA, El-Kashef TA, Abdelaziz AS, Ali MM. Impact of genital hygiene and sexual activity on urinary tract infection during pregnancy. Urol Ann 2015;7:78-81.
11. Schneeberger C, Erwich JJ, Van Den Heuvel E, Mol B, Ott A, Geerlings SE. Asymptomatic bacteriuria and urinary tract infection in pregnant women with and without diabetes: Cohort study. Eur J Obstet Gynecol in press 2018 (N. del T.: En español: En prensa)
12. Lumbiganon P, Laopaiboon M, Thinkhamrop J. Screening and treating asymptomatic bacteriuria in pregnancy. Curr Opin Obstet Gynecol. 2010;22:95-9.
13. Smaill F. Asymptomatic bacteriuria in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2007 Jun;21(3):439-50
14. Geerlings SE. Clinical Presentations and Epidemiology of Urinary Tract Infections. Microbiol Spectr. 2016 Oct;4(5)
15. Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM, et al. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis Off Publ Infect Dis Soc Am. 2005;40:643-54.
16. Martínez E, Osorio J, Delgado J, Esparza G, Motoa G, Blanco VM, et al. Infecciones del tracto urinario bajo en adultos y embarazadas: Consenso para el
manejo empírico. Infectio.2013;17:122-35.
17. Gilbert NM, O’brien VP, Hultgren S, Macones G, Lewis WG, Lewis AL. Urinary Tract Infection as a Preventable Cause of Pregnancy Complications: Opportunities,
Challenges, and a Global Call to Action. Glob Adv Health Med. 2013 Sep;2(5):59-69.
18. Nicolle LE. Asymptomatic bacteriuria: when to screen and when to treat. Infect DisClin N Am 17 2003; 367–394
19. Kim SJ, Parikh P, King AN, Marnach ML. Asymptomatic bacteriuria in pregnancy complicated by pyelonephritis requiring nephrectomy. Case Reports in Obstetrics
and Gynecology, vol. 2018, Article ID 8924823, 4 pages
20. Fátima N, Ishrat S. Frecuency and risk factors of asintomatic bacteriuria during pregnancy. J Coll Physicians Surg Pak. 2006 Apr;16(4):273-5.
21. Matuszkiewicz-Rowińska J, Małyszko J, Wieliczko M. Urinary tract infections in pregnancy: old and new unresolved diagnostic and therapeutic problems. Arch Med
Sci. 2015 Mar 16;11(1):67-77
22. Jido TA. Urinary tract infections in pregnancy: Evaluation of diagnostic framework. Saudi J Kidney Dis Transpl 2014;25:85-90
23. Etminan-Bakhsh M, Tadi S, Darabi R. Asymptomatic bacteriuria in pregnant women attending Boo-Ali Hospital Tehran Iran: Urine analysis vs. urine culture.
Electronic physician 2017; 9(11): 5760-5763.
24. Gomi H, Goto Y, Laopaiboon M, Usui R, Mori R. Routine blood cultures in the management of pyelonephritis in pregnancy for improving outcomes. Cochrane
Database of Systematic Reviews 2015, Issue 2. Art. No.: CD009216
25. Reyes A, Gómez A, Rodríguez JA. Validez del parcial de orina y el Gram en el diagnóstico de infección del tracto urinario en el embarazo. Hospital Simón Bolívar,
Bogotá, Colombia, 2009-2010. Rev Col Obs Gin 2013;64(1), 53–59.
26. Estrada A, Figueroa R, Villagrana R. Infección de vías urinarias en la mujer embarazada. Importancia del escrutinio de bacteriuria asintomática durante la
gestación. Perinatol Reprod Hum 2010; 24 (3):182-186
27. Feitosa DCA, Silva MG, Parada CMGL. Accuracy of simple urine tests for diagnosis of urinary tract infections in low-risk pregnant women. Rev Latino-am
Enfermagem 2009; 17(4):507-13
28. Angelescu K, Nussbaumer-Streit B, Sieben W, Scheibler F, Gartlehner G. Benefits and harms of screening for and treatment of asymptomatic bacteriuria in pregnancy:
a systematic review. BMC Pregnancy and Childbirth 2016;16:336
29. Dutch Society for Obstetrics and Gynaecology. NVOG guideline: urinary tract infections during pregnancy. 2011
30. Alós JI, Andreu A, Arribas L, Cabero L, De Cueto M, López J et al. Prevención de la infección perinatal por estreptococo del grupo B. Recomendaciones españolas.
Actualización 2012. Documento de consenso SEIMC/SEGO/SEN/SEQ/SEMFYC. Enferm Infecc Microbiol Clin. 2013;31(3):159–172.
31. Smaill FM, Vazquez JC. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database Syst Rev. 2015;8(8)
32. Kazemier BM, Koningstein FN, Schneeberger C, Ott A, Bossuyt PM, de Miranda E, et al. Maternal and neonatal consequences of treated and untreated asymptomatic
bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial. The Lancet Infectious diseases. 2015;15(11):1324–33
33. Farkash E, Weintraub AY, Sergienko R, Wiznitzer A, Zlotnik A, Sheiner E. Acute antepartum pyelonephritis in pregnancy: a critical analysis of risk factors and
outcomes. Eur J Obstet Gynecol Reprod Biol. 2012 May;162 (1):24-7.
34. Petry CJ, Ong KK, Hughes IA, Acerini CL, Dunger DB. Associations between bacterial infections and blood pressure in pregnancy. Pregnancy Hypertens. 2017
Oct;10:202-206
35. Easter SR, Cantonwine DE, Zera CA, Lim K, Parry S, McElrath T. Urinary tract infection during pregnancy, angiogenic factor profiles, and risk of preeclampsia. Am
J Obstet Gynecol 2016;214:387.e1-7.
36. Liu J, Chiu F, Liu Y, Chen S, Chan H, Yang J et al. Antepartum urinary tract infection and postpartum depression in Taiwan – a nationwide population-based
study. BMC Pregnancy and Childbirth 2018;18:79
37. Bolton M, Horvath DJ Jr, Li B, Cortado H, Newsom D, White P et al. Intrauterine Growth Restriction Is a Direct Consequence of Localized Maternal Uropathogenic
Escherichia coli Cystitis. PLoS ONE 7(3): e33897.
38. Leviton A, Allred EN, Kuban KC, O'Shea TM, Paneth N, Onderdonk AB et al. The Development of Extremely Preterm Infants Born to Women Who Had
Genitourinary Infections During Pregnancy. Am J Epidemiol. 2016 Jan 1;183(1):28-35.
39. Kapaya H, Williams R, Elton G, Anumba D. Can Obstetric Risk Factors Predict Fetal Acidaemia at Birth? A Retrospective Case-Control Study. Journal of
Pregnancy, 2018, 1-8
40. Howley MM, Feldkamp ML, Papadopoulos EA, Fisher SC, Arnold KE, Browne ML. Maternal genitourinary infections and risk of birth defects in the National Birth
Defects Prevention Study. Birth Defects Res. 2018 Nov 15;110(19):1443-1454.
41. Ailes EC, Gilboa SM, Gill SK, Broussard CS, Crider KS, Berry RJ. Association between Antibiotic Use among Pregnant Women with Urinary Tract Infections in
the First Trimester and Birth Defects. National Birth Defects Prevention Study 1997 to 2011. Birth Defects Res A Clin Mol Teratol. 2016 Nov;106(11):940-949.
42. Verani JR, McGee L, Schrag SJ. Centers for Disease Control and Prevention: Prevention of Perinatal Group B Streptococcal Disease: Revised Guidelines from
CDC, 2010. MMWR Recomm Rep. 2010 Nov 19;59(RR-10):1-36
43. Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. The Lancet, 2017 Oct 14;390(10104):1770-1780.
44. Fichorova RN, Beatty N, Sassi RRS, Yamamoto HS, Allred EN, Leviton A, et al.Systemic inflammation in the extremely low gestational age newborn following
maternal genitourinary infections. Am J Reprod Immunol 2015; 73: 162–174
45. Smaill F, Vazquez JC. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database Syst Rev. 2007;2(2).
46. Pavón NJ. Diagnóstico y tratamiento de infección de las vías urinarias en embarazadas que acuden a Emergencia y consulta externa del Hospital Bertha
Calderón Roque en Managua, Nicaragua. Perinatol Reprod Hum 2013; 27 (1): 15-20
47. Artero A, Alberola J, Eiros JM, Nogueira JM, Cano A. Pyelonephritis in pregnancy. How adequate is empirical treatment ?. Rev Esp Quimioter. 2013 Mar;26(1):30-3.
48. Herrera M, Gómez M. Resistencia bacteriana en urocultivos de una población de embarazadas de control prenatal en Bogotá junio 2013 – junio 2015. Biociencias,
13(2), 111-124.
49. Vazquez JC, Abalos E. Treatments for symptomatic urinary tract infections during pregnancy. Cochrane Database Syst Rev. 2011 Jan 19;(1):CD002256.
50. Ghouri F, Hollywood A, Ryan K. A systematic review of non-antibiotic measures for the prevention of urinary tract infections in pregnancy. BMC Pregnancy and
Childbirth 2018; 18:99
51. Schneeberger C, Geerlings SE, Middleton P, Crowther CA. Interventions for preventing recurrent urinary tract infection during pregnancy. Cochrane Database
Syst Rev. 2015 Jul 26;(7):CD009279.
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2019-05-09
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Cómo citar
INFECCIÓN URINARIA GESTACIONAL COMO FUENTE DE COMPLICACIONES PERINATALES Y PUERPERALES. (2019). Biociencias, 14(1), 141-153. https://doi.org/10.18041/2390-0512/biociencias.1.5341
